:root {
  --navy-950: #071a31;
  --navy-900: #0b2442;
  --navy-800: #10365d;
  --blue-700: #075d9a;
  --blue-600: #0a72b8;
  --blue-500: #168bc8;
  --teal-500: #49a7a1;
  --ice-100: #eff8fc;
  --ice-200: #e2f2f8;
  --white: #ffffff;
  --ink: #102844;
  --muted: #5d7289;
  --line: #c9dce8;
  --line-strong: #a9c9db;
  --panel: rgba(255, 255, 255, 0.9);
  --shadow-soft: 0 24px 70px rgba(18, 66, 101, 0.12);
  --shadow-card: 0 18px 42px rgba(18, 66, 101, 0.11);
  --radius-xl: 34px;
  --radius-lg: 24px;
  --radius-md: 18px;
  --max-width: 1180px;
  --topbar-height: 72px;
}

* {
  box-sizing: border-box;
}

html {
  scroll-behavior: smooth;
  scroll-padding-top: calc(var(--topbar-height) + 24px);
}

body {
  margin: 0;
  min-width: 320px;
  color: var(--ink);
  background:
    radial-gradient(circle at 78% 6%, rgba(114, 201, 216, 0.18), transparent 25%),
    linear-gradient(180deg, #f8fbfd 0%, #eef7fb 48%, #f8fbfd 100%);
  font-family: Inter, ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
  line-height: 1.5;
  overflow-x: hidden;
}

body.nav-open {
  overflow: hidden;
}

button,
a {
  font: inherit;
}

a {
  color: inherit;
  text-decoration: none;
}

p,
h1,
h2,
h3 {
  margin-top: 0;
}

.sr-only {
  position: absolute;
  width: 1px;
  height: 1px;
  padding: 0;
  margin: -1px;
  overflow: hidden;
  clip: rect(0, 0, 0, 0);
  white-space: nowrap;
  border: 0;
}

#molecular-field {
  position: fixed;
  inset: var(--topbar-height) 0 0;
  z-index: -4;
  width: 100%;
  height: calc(100% - var(--topbar-height));
  opacity: 0.7;
  pointer-events: none;
}

.background-glow,
.background-vignette {
  position: fixed;
  inset: var(--topbar-height) 0 0;
  pointer-events: none;
}

.background-glow {
  z-index: -3;
  background:
    radial-gradient(circle at 50% 21%, rgba(255, 255, 255, 0.98) 0%, rgba(255, 255, 255, 0.76) 28%, transparent 63%),
    radial-gradient(circle at 84% 54%, rgba(91, 177, 199, 0.12), transparent 35%);
}

.background-vignette {
  z-index: -2;
  box-shadow: inset 0 0 180px rgba(23, 72, 108, 0.08);
}

.topbar {
  position: sticky;
  top: 0;
  z-index: 100;
  height: var(--topbar-height);
  display: grid;
  grid-template-columns: auto 1fr auto;
  align-items: center;
  gap: 30px;
  padding: 0 30px;
  color: var(--white);
  background: linear-gradient(110deg, #0a3765 0%, #075a94 62%, #0875ae 100%);
  border-bottom: 1px solid rgba(255, 255, 255, 0.18);
  box-shadow: 0 8px 26px rgba(7, 42, 78, 0.14);
}

.brand {
  display: inline-flex;
  align-items: center;
  gap: 12px;
  width: fit-content;
  font-weight: 800;
  letter-spacing: 0.04em;
}

.brand-mark {
  width: 38px;
  height: 38px;
  display: grid;
  place-items: center;
  border: 1px solid rgba(255, 255, 255, 0.55);
  border-radius: 12px;
  background: rgba(255, 255, 255, 0.08);
  box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.2);
}

.brand-mark svg {
  width: 25px;
  height: 25px;
  fill: none;
  stroke: currentColor;
  stroke-width: 1.7;
  stroke-linecap: round;
}

.brand-name {
  font-size: 0.98rem;
}

.site-nav {
  justify-self: center;
  display: flex;
  align-items: center;
  gap: 26px;
}

.site-nav a {
  position: relative;
  color: rgba(255, 255, 255, 0.82);
  font-size: 0.86rem;
  font-weight: 700;
  letter-spacing: 0.03em;
}

.site-nav a::after {
  content: "";
  position: absolute;
  left: 0;
  bottom: -8px;
  width: 100%;
  height: 2px;
  border-radius: 99px;
  background: var(--white);
  transform: scaleX(0);
  transform-origin: center;
  transition: transform 180ms ease;
}

.site-nav a:hover::after,
.site-nav a:focus-visible::after,
.site-nav a.is-active::after {
  transform: scaleX(1);
}

.topbar-kicker {
  justify-self: end;
  font-size: 0.78rem;
  font-weight: 800;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  white-space: nowrap;
}

.menu-button {
  display: none;
  width: 42px;
  height: 42px;
  border: 1px solid rgba(255, 255, 255, 0.38);
  border-radius: 12px;
  background: rgba(255, 255, 255, 0.08);
  cursor: pointer;
}

.menu-button span:not(.sr-only) {
  display: block;
  width: 19px;
  height: 2px;
  margin: 4px auto;
  border-radius: 99px;
  background: var(--white);
  transition: transform 180ms ease, opacity 180ms ease;
}

.hero {
  min-height: calc(100vh - var(--topbar-height));
  display: grid;
  place-items: center;
  padding: 72px 24px 88px;
}

.hero-panel,
.section-shell {
  width: min(100%, var(--max-width));
  margin: 0 auto;
  border: 1px solid rgba(146, 187, 211, 0.55);
  background: var(--panel);
  backdrop-filter: blur(18px);
  -webkit-backdrop-filter: blur(18px);
  box-shadow: var(--shadow-soft);
}

.hero-panel {
  position: relative;
  overflow: hidden;
  padding: 62px 56px 30px;
  border-radius: var(--radius-xl);
}

.hero-panel::before {
  content: "";
  position: absolute;
  inset: -40% 45% auto -12%;
  height: 500px;
  border-radius: 50%;
  background: radial-gradient(circle, rgba(102, 186, 205, 0.16), transparent 68%);
  pointer-events: none;
}

.hero-layout {
  position: relative;
  display: grid;
  grid-template-columns: minmax(0, 1.12fr) minmax(330px, 0.88fr);
  align-items: center;
  gap: 44px;
}

.hero-copy {
  position: relative;
  z-index: 2;
}

.eyebrow {
  display: flex;
  align-items: center;
  gap: 12px;
  margin-bottom: 16px;
  color: var(--blue-700);
  font-size: 0.78rem;
  font-weight: 800;
  letter-spacing: 0.16em;
  text-transform: uppercase;
}

.eyebrow span {
  width: 44px;
  height: 1px;
  background: var(--line-strong);
}

.hero h1 {
  margin-bottom: 2px;
  color: var(--blue-700);
  font-size: clamp(4.6rem, 8.5vw, 7.25rem);
  line-height: 0.92;
  letter-spacing: -0.065em;
}

.hero h2 {
  margin-bottom: 20px;
  max-width: 760px;
  color: var(--navy-950);
  font-size: clamp(2rem, 3.2vw, 3.1rem);
  line-height: 1.08;
  letter-spacing: -0.04em;
}

.hero-lede {
  max-width: 690px;
  margin-bottom: 28px;
  color: var(--muted);
  font-size: clamp(1.05rem, 1.55vw, 1.25rem);
  line-height: 1.65;
}

.hero-actions,
.opportunity-actions {
  display: flex;
  flex-wrap: wrap;
  align-items: center;
  gap: 12px;
}

.button {
  min-height: 48px;
  display: inline-flex;
  align-items: center;
  justify-content: center;
  padding: 0 20px;
  border: 1px solid transparent;
  border-radius: 14px;
  font-size: 0.92rem;
  font-weight: 800;
  transition: transform 180ms ease, box-shadow 180ms ease, background 180ms ease;
}

.button:hover,
.button:focus-visible {
  transform: translateY(-2px);
}

.button-primary {
  color: var(--white);
  background: linear-gradient(135deg, var(--blue-700), var(--blue-500));
  box-shadow: 0 12px 24px rgba(7, 93, 154, 0.22);
}

.button-secondary {
  color: var(--blue-700);
  border-color: var(--line-strong);
  background: rgba(255, 255, 255, 0.7);
}

.hero-visual {
  position: relative;
  min-height: 430px;
  display: grid;
  place-items: center;
}

.orbit {
  position: absolute;
  border: 1px solid rgba(48, 126, 172, 0.18);
  border-radius: 50%;
}

.orbit-one {
  width: 405px;
  height: 405px;
  animation: orbitPulse 7s ease-in-out infinite;
}

.orbit-two {
  width: 330px;
  height: 330px;
  animation: orbitPulse 7s ease-in-out 1.4s infinite;
}

.nanoparticle {
  position: relative;
  width: 268px;
  aspect-ratio: 1;
  border-radius: 50%;
  filter: drop-shadow(0 26px 28px rgba(14, 72, 105, 0.22));
  animation: particleFloat 6s ease-in-out infinite;
}

.particle-shell {
  position: absolute;
  inset: 0;
  border: 2px solid rgba(17, 73, 105, 0.45);
  border-radius: 50%;
  background:
    radial-gradient(circle at 35% 25%, rgba(255, 255, 255, 0.8), transparent 16%),
    radial-gradient(circle at 68% 69%, rgba(20, 118, 154, 0.22), transparent 28%),
    linear-gradient(145deg, rgba(154, 220, 213, 0.96), rgba(82, 164, 171, 0.9));
  box-shadow:
    inset 0 0 0 16px rgba(255, 255, 255, 0.16),
    inset 0 -22px 42px rgba(15, 85, 113, 0.18),
    0 0 0 13px rgba(255, 255, 255, 0.48);
}

.payload-core {
  position: absolute;
  inset: 67px;
  z-index: 2;
  overflow: hidden;
  border: 2px solid rgba(111, 93, 48, 0.36);
  border-radius: 50%;
  background:
    radial-gradient(circle at 35% 28%, rgba(255, 255, 255, 0.7), transparent 14%),
    linear-gradient(145deg, #e8e0b6, #b5c39e);
  box-shadow: inset 0 -18px 30px rgba(83, 94, 62, 0.18);
}

.payload-dot {
  position: absolute;
  width: 7px;
  height: 7px;
  border-radius: 50%;
  background: rgba(80, 89, 60, 0.58);
  box-shadow: 0 0 0 2px rgba(255, 255, 255, 0.24);
}

.surface-antibody {
  position: absolute;
  left: calc(50% - 2px);
  top: calc(50% - 52px);
  z-index: 4;
  width: 5px;
  height: 56px;
  border-radius: 99px;
  background: linear-gradient(180deg, #7ba9c8 0 28%, #164973 29% 100%);
  transform: rotate(var(--angle)) translateY(-111px);
  transform-origin: 2px 52px;
  box-shadow: 0 0 0 1px rgba(8, 40, 66, 0.25);
}

.surface-antibody span,
.surface-antibody span::before,
.surface-antibody span::after {
  position: absolute;
  display: block;
  border-radius: 99px;
  background: #8db8d3;
  box-shadow: 0 0 0 1px rgba(8, 40, 66, 0.32);
}

.surface-antibody span {
  top: -4px;
  left: 0;
  width: 5px;
  height: 19px;
}

.surface-antibody span::before,
.surface-antibody span::after {
  content: "";
  top: -1px;
  width: 5px;
  height: 20px;
  transform-origin: bottom center;
}

.surface-antibody span::before {
  left: -6px;
  transform: rotate(-39deg);
}

.surface-antibody span::after {
  right: -6px;
  transform: rotate(39deg);
}

.particle-label {
  position: absolute;
  z-index: 8;
  padding: 7px 10px;
  border: 1px solid rgba(151, 188, 208, 0.78);
  border-radius: 10px;
  color: var(--navy-800);
  background: rgba(255, 255, 255, 0.84);
  box-shadow: 0 8px 20px rgba(19, 65, 96, 0.1);
  font-size: 0.69rem;
  font-weight: 800;
  white-space: nowrap;
}

.label-targeting {
  top: -40px;
  right: -35px;
}

.label-shell {
  right: -62px;
  bottom: 75px;
}

.label-payload {
  left: -50px;
  bottom: 34px;
}

.hero-cards {
  position: relative;
  z-index: 4;
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 16px;
  margin-top: 32px;
}

.feature-card {
  min-height: 220px;
  display: flex;
  flex-direction: column;
  padding: 24px;
  border: 1px solid var(--line);
  border-radius: var(--radius-md);
  background: rgba(255, 255, 255, 0.84);
  box-shadow: 0 14px 32px rgba(18, 66, 101, 0.08);
  transition: transform 200ms ease, box-shadow 200ms ease, border-color 200ms ease;
}

.feature-card:hover,
.feature-card:focus-visible {
  transform: translateY(-5px);
  border-color: #83b7d4;
  box-shadow: var(--shadow-card);
}

.feature-card-active {
  color: var(--white);
  border-color: transparent;
  background: linear-gradient(145deg, #07508b, #0875b7);
  box-shadow: 0 20px 36px rgba(7, 86, 144, 0.25);
}

.feature-icon {
  width: 38px;
  height: 38px;
  display: grid;
  place-items: center;
  margin-bottom: 22px;
  border: 1px solid #bad8e9;
  border-radius: 12px;
  color: var(--blue-700);
  background: var(--ice-100);
  font-size: 0.72rem;
  font-weight: 900;
}

.feature-card-active .feature-icon {
  color: var(--white);
  border-color: rgba(255, 255, 255, 0.28);
  background: rgba(255, 255, 255, 0.12);
}

.feature-card h3 {
  margin-bottom: 7px;
  font-size: 1.1rem;
  letter-spacing: -0.02em;
}

.feature-card p {
  margin-bottom: 20px;
  color: var(--muted);
  font-size: 0.9rem;
  line-height: 1.52;
}

.feature-card-active p {
  color: rgba(255, 255, 255, 0.8);
}

.feature-card strong {
  margin-top: auto;
  color: var(--blue-700);
  font-size: 0.86rem;
}

.feature-card-active strong {
  color: var(--white);
}

.hero-note {
  position: relative;
  z-index: 2;
  margin: 28px 0 0;
  color: #698097;
  text-align: center;
  font-size: 0.82rem;
  font-weight: 700;
}

.content-section {
  padding: 54px 24px;
}

.section-shell {
  padding: 72px 64px;
  border-radius: var(--radius-xl);
}

.section-heading {
  max-width: 910px;
  margin-bottom: 52px;
}

.section-heading.compact {
  margin-bottom: 40px;
}

.section-number {
  margin-bottom: 16px;
  color: var(--blue-700);
  font-size: 0.75rem;
  font-weight: 900;
  letter-spacing: 0.14em;
  text-transform: uppercase;
}

.section-number.light {
  color: #aee4f5;
}

.section-heading h1,
.section-heading h2,
.opportunity-copy h2 {
  margin-bottom: 22px;
  color: var(--navy-950);
  font-size: clamp(2.25rem, 4.2vw, 4.25rem);
  line-height: 1.05;
  letter-spacing: -0.05em;
}

.section-lede {
  max-width: 840px;
  margin-bottom: 0;
  color: var(--muted);
  font-size: 1.08rem;
  line-height: 1.72;
}

.comparison-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 20px;
  margin-bottom: 22px;
}

.comparison-card {
  min-height: 430px;
  padding: 28px;
  border: 1px solid var(--line);
  border-radius: var(--radius-lg);
  background: rgba(255, 255, 255, 0.7);
}

.comparison-card-highlight {
  background: linear-gradient(155deg, rgba(224, 246, 247, 0.92), rgba(235, 246, 252, 0.94));
}

.comparison-label {
  display: inline-flex;
  padding: 7px 11px;
  border: 1px solid var(--line);
  border-radius: 999px;
  color: var(--blue-700);
  background: rgba(255, 255, 255, 0.62);
  font-size: 0.72rem;
  font-weight: 900;
  letter-spacing: 0.08em;
  text-transform: uppercase;
}

.comparison-card h3 {
  margin-bottom: 10px;
  color: var(--navy-950);
  font-size: 1.36rem;
}

.comparison-card p {
  margin-bottom: 0;
  color: var(--muted);
}

.adc-diagram,
.mini-particle {
  position: relative;
  height: 228px;
  display: grid;
  place-items: center;
}

.antibody-large {
  position: relative;
  width: 120px;
  height: 142px;
  transform: translateX(-62px);
}

.antibody-arm,
.antibody-stem {
  position: absolute;
  display: block;
  border-radius: 999px;
  background: linear-gradient(180deg, #7caed0, #0e4f80);
}

.antibody-arm {
  top: 12px;
  width: 18px;
  height: 92px;
  transform-origin: bottom center;
}

.arm-left {
  left: 34px;
  transform: rotate(-39deg);
}

.arm-right {
  right: 34px;
  transform: rotate(39deg);
}

.antibody-stem {
  left: calc(50% - 9px);
  bottom: 8px;
  width: 18px;
  height: 77px;
}

.linker {
  position: absolute;
  left: 53%;
  width: 95px;
  height: 5px;
  border-radius: 99px;
  background: repeating-linear-gradient(90deg, #49a7a1 0 10px, transparent 10px 15px);
}

.payload-dots {
  position: absolute;
  left: calc(53% + 96px);
  display: flex;
  gap: 7px;
}

.payload-dots i {
  width: 13px;
  height: 13px;
  border: 2px solid #934038;
  border-radius: 50%;
  background: #ef7460;
}

.mini-particle {
  width: 228px;
  margin: 0 auto;
}

.mini-shell,
.mini-core,
.mini-spokes {
  position: absolute;
  border-radius: 50%;
}

.mini-shell {
  width: 165px;
  height: 165px;
  border: 2px solid rgba(17, 73, 105, 0.42);
  background: linear-gradient(145deg, #a7ddd6, #559fa8);
  box-shadow: 0 0 0 12px rgba(255, 255, 255, 0.52), 0 22px 32px rgba(14, 72, 105, 0.14);
}

.mini-core {
  width: 90px;
  height: 90px;
  border: 2px solid rgba(107, 95, 63, 0.36);
  background: radial-gradient(circle at 38% 30%, #f7f1d4, #b9c19a);
}

.mini-spokes {
  width: 202px;
  height: 202px;
  border: 8px dotted #1b5b82;
  opacity: 0.82;
}

.layer-grid,
.metric-grid,
.review-grid {
  display: grid;
  gap: 18px;
}

.layer-grid {
  grid-template-columns: repeat(3, minmax(0, 1fr));
}

.layer-card {
  position: relative;
  min-height: 190px;
  padding: 28px;
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: var(--radius-md);
  background: rgba(255, 255, 255, 0.76);
}

.layer-index {
  position: absolute;
  top: 17px;
  right: 20px;
  color: rgba(7, 93, 154, 0.18);
  font-size: 2.7rem;
  font-weight: 900;
}

.layer-card h3 {
  margin-bottom: 12px;
  font-size: 1.24rem;
}

.layer-card p {
  margin-bottom: 0;
  color: var(--muted);
}

.evidence-section .section-shell {
  background: linear-gradient(145deg, rgba(255, 255, 255, 0.94), rgba(232, 248, 250, 0.92));
}

.metric-grid {
  grid-template-columns: repeat(4, minmax(0, 1fr));
  margin-bottom: 22px;
}

.metric-card {
  min-height: 270px;
  padding: 28px 24px;
  border: 1px solid var(--line);
  border-radius: var(--radius-md);
  background: rgba(255, 255, 255, 0.82);
  box-shadow: 0 14px 28px rgba(18, 66, 101, 0.07);
}

.metric-value {
  margin-bottom: 18px;
  color: var(--blue-700);
  font-size: clamp(2.8rem, 5vw, 4.6rem);
  font-weight: 850;
  line-height: 1;
  letter-spacing: -0.055em;
}

.metric-card h3 {
  margin-bottom: 9px;
  font-size: 1.09rem;
}

.metric-card p {
  margin-bottom: 0;
  color: var(--muted);
  font-size: 0.9rem;
}

.evidence-callout {
  display: grid;
  grid-template-columns: 0.86fr 1.14fr;
  gap: 34px;
  align-items: center;
  padding: 34px;
  border: 1px solid #9dc9d8;
  border-radius: var(--radius-lg);
  color: var(--white);
  background: linear-gradient(125deg, #0d365b, #0b6f99);
}

.callout-kicker {
  margin-bottom: 8px;
  color: #aee4f5;
  font-size: 0.73rem;
  font-weight: 900;
  letter-spacing: 0.1em;
  text-transform: uppercase;
}

.evidence-callout h3 {
  margin-bottom: 0;
  font-size: 1.65rem;
  line-height: 1.2;
}

.evidence-callout ol {
  display: grid;
  gap: 11px;
  margin: 0;
  padding: 0;
  list-style: none;
}

.evidence-callout li {
  display: flex;
  align-items: center;
  gap: 12px;
  color: rgba(255, 255, 255, 0.86);
  font-size: 0.92rem;
}

.evidence-callout li span {
  width: 34px;
  height: 34px;
  flex: 0 0 auto;
  display: grid;
  place-items: center;
  border: 1px solid rgba(255, 255, 255, 0.26);
  border-radius: 10px;
  color: var(--white);
  background: rgba(255, 255, 255, 0.08);
  font-size: 0.7rem;
  font-weight: 900;
}

.pipeline-table {
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: var(--radius-lg);
  background: rgba(255, 255, 255, 0.74);
}

.pipeline-row {
  display: grid;
  grid-template-columns: 0.72fr 1.15fr 2fr;
  gap: 20px;
  align-items: center;
  padding: 26px 28px;
  border-bottom: 1px solid var(--line);
}

.pipeline-row:last-child {
  border-bottom: 0;
}

.pipeline-header {
  padding-top: 16px;
  padding-bottom: 16px;
  color: var(--muted);
  background: rgba(222, 239, 247, 0.65);
  font-size: 0.72rem;
  font-weight: 900;
  letter-spacing: 0.1em;
  text-transform: uppercase;
}

.pipeline-row strong,
.pipeline-row span {
  display: block;
}

.pipeline-row strong {
  margin-bottom: 4px;
  color: var(--navy-950);
  font-size: 1.05rem;
}

.pipeline-row > div > span {
  color: var(--muted);
  font-size: 0.82rem;
}

.stage-labels {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  margin-bottom: 8px;
  color: #7a8ea2;
  font-size: 0.68rem;
}

.stage-labels span:not(:first-child) {
  text-align: center;
}

.stage-track {
  height: 10px;
  overflow: hidden;
  border-radius: 999px;
  background: #dcebf2;
}

.stage-track span {
  height: 100%;
  border-radius: inherit;
  background: linear-gradient(90deg, var(--teal-500), var(--blue-600));
  box-shadow: 0 0 18px rgba(22, 139, 200, 0.3);
}

.opportunity-section {
  padding-top: 70px;
  padding-bottom: 70px;
}

.opportunity-panel {
  width: min(100%, var(--max-width));
  margin: 0 auto;
  display: grid;
  grid-template-columns: 0.88fr 1.12fr;
  gap: 44px;
  padding: 70px 64px;
  border: 1px solid rgba(130, 201, 225, 0.42);
  border-radius: var(--radius-xl);
  color: var(--white);
  background:
    radial-gradient(circle at 15% 15%, rgba(79, 180, 190, 0.22), transparent 32%),
    linear-gradient(145deg, #081e39 0%, #0c3f67 52%, #0879a6 100%);
  box-shadow: 0 30px 70px rgba(8, 46, 79, 0.22);
}

.opportunity-copy h2 {
  color: var(--white);
}

.opportunity-copy > p:not(.section-number) {
  margin-bottom: 28px;
  color: rgba(255, 255, 255, 0.76);
  font-size: 1.04rem;
  line-height: 1.72;
}

.button-light {
  color: var(--blue-700);
  background: var(--white);
  box-shadow: 0 12px 24px rgba(2, 28, 49, 0.18);
}

.text-link-light {
  color: rgba(255, 255, 255, 0.88);
  font-size: 0.9rem;
  font-weight: 800;
}

.milestone-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 14px;
}

.milestone-grid article {
  min-height: 205px;
  padding: 24px;
  border: 1px solid rgba(255, 255, 255, 0.17);
  border-radius: var(--radius-md);
  background: rgba(255, 255, 255, 0.07);
  backdrop-filter: blur(8px);
}

.milestone-grid article > span {
  color: #aee4f5;
  font-size: 0.72rem;
  font-weight: 900;
  letter-spacing: 0.08em;
}

.milestone-grid h3 {
  margin: 25px 0 8px;
  font-size: 1.06rem;
}

.milestone-grid p {
  margin-bottom: 0;
  color: rgba(255, 255, 255, 0.68);
  font-size: 0.88rem;
}

.review-section {
  padding-bottom: 90px;
}

.review-shell {
  background: rgba(255, 255, 255, 0.92);
}

.review-grid {
  grid-template-columns: repeat(4, minmax(0, 1fr));
  margin-bottom: 20px;
}

.review-grid article {
  min-height: 185px;
  padding: 24px;
  border: 1px solid var(--line);
  border-radius: var(--radius-md);
  background: #f9fcfe;
}

.review-grid h3 {
  margin-bottom: 9px;
  font-size: 1.04rem;
}

.review-grid p {
  margin-bottom: 0;
  color: var(--muted);
  font-size: 0.88rem;
}

.legal-note {
  padding: 24px 28px;
  border-left: 4px solid var(--blue-600);
  border-radius: 0 var(--radius-md) var(--radius-md) 0;
  background: var(--ice-100);
}

.legal-note strong {
  display: block;
  margin-bottom: 5px;
}

.legal-note p {
  margin-bottom: 0;
  color: var(--muted);
  font-size: 0.88rem;
}

.site-footer {
  min-height: 110px;
  display: grid;
  grid-template-columns: auto 1fr auto;
  align-items: center;
  gap: 28px;
  padding: 26px max(24px, calc((100vw - var(--max-width)) / 2));
  color: rgba(255, 255, 255, 0.8);
  background: var(--navy-950);
}

.footer-brand .brand-mark {
  color: var(--white);
}

.site-footer p {
  margin-bottom: 0;
  font-size: 0.78rem;
  text-align: center;
}

.site-footer > a:last-child {
  color: var(--white);
  font-size: 0.82rem;
  font-weight: 800;
}

[data-reveal] {
  opacity: 0;
  transform: translateY(20px);
  transition: opacity 700ms ease, transform 700ms cubic-bezier(0.2, 0.75, 0.2, 1);
}

[data-reveal].is-visible {
  opacity: 1;
  transform: translateY(0);
}

@keyframes particleFloat {
  0%, 100% { transform: translateY(0) rotate(-1deg); }
  50% { transform: translateY(-10px) rotate(1deg); }
}

@keyframes orbitPulse {
  0%, 100% { transform: scale(0.98); opacity: 0.48; }
  50% { transform: scale(1.04); opacity: 0.9; }
}

@media (max-width: 1050px) {
  .topbar {
    grid-template-columns: auto 1fr auto;
  }

  .topbar-kicker {
    display: none;
  }

  .site-nav {
    justify-self: end;
  }

  .hero-layout {
    grid-template-columns: 1fr;
  }

  .hero-copy {
    text-align: center;
  }

  .eyebrow,
  .hero-actions {
    justify-content: center;
  }

  .hero-lede {
    margin-right: auto;
    margin-left: auto;
  }

  .hero-visual {
    min-height: 390px;
  }

  .metric-grid,
  .review-grid {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }

  .opportunity-panel {
    grid-template-columns: 1fr;
  }
}

@media (max-width: 780px) {
  :root {
    --topbar-height: 64px;
  }

  .topbar {
    grid-template-columns: 1fr auto;
    padding: 0 16px;
  }

  .menu-button {
    display: block;
  }

  .site-nav {
    position: fixed;
    inset: var(--topbar-height) 0 auto;
    display: grid;
    gap: 0;
    padding: 12px 18px 24px;
    color: var(--white);
    background: #0a3765;
    box-shadow: 0 24px 40px rgba(7, 31, 57, 0.22);
    transform: translateY(-120%);
    opacity: 0;
    pointer-events: none;
    transition: transform 220ms ease, opacity 220ms ease;
  }

  .site-nav.is-open {
    transform: translateY(0);
    opacity: 1;
    pointer-events: auto;
  }

  .site-nav a {
    padding: 17px 4px;
    border-bottom: 1px solid rgba(255, 255, 255, 0.12);
    font-size: 0.95rem;
  }

  .site-nav a::after {
    display: none;
  }

  .hero {
    padding: 34px 14px 56px;
  }

  .hero-panel,
  .section-shell,
  .opportunity-panel {
    border-radius: 24px;
  }

  .hero-panel {
    padding: 42px 20px 24px;
  }

  .eyebrow span {
    width: 22px;
  }

  .hero h1 {
    font-size: clamp(4rem, 21vw, 6rem);
  }

  .hero h2 {
    font-size: clamp(2rem, 9.5vw, 3rem);
  }

  .hero-visual {
    min-height: 350px;
    transform: scale(0.9);
  }

  .hero-cards,
  .comparison-grid,
  .layer-grid,
  .evidence-callout,
  .pipeline-row,
  .opportunity-panel,
  .site-footer {
    grid-template-columns: 1fr;
  }

  .feature-card {
    min-height: 190px;
  }

  .content-section {
    padding: 34px 14px;
  }

  .section-shell,
  .opportunity-panel {
    padding: 48px 22px;
  }

  .section-heading h1,
  .section-heading h2,
  .opportunity-copy h2 {
    font-size: clamp(2.15rem, 10vw, 3.25rem);
  }

  .comparison-card {
    min-height: 395px;
  }

  .metric-grid,
  .review-grid,
  .milestone-grid {
    grid-template-columns: 1fr;
  }

  .metric-card {
    min-height: 220px;
  }

  .pipeline-header {
    display: none;
  }

  .pipeline-row {
    gap: 18px;
    padding: 24px 20px;
  }

  .pipeline-row > div::before {
    display: block;
    margin-bottom: 5px;
    color: var(--blue-700);
    font-size: 0.65rem;
    font-weight: 900;
    letter-spacing: 0.08em;
    text-transform: uppercase;
  }

  .pipeline-row > div:nth-child(1)::before { content: "Program"; }
  .pipeline-row > div:nth-child(2)::before { content: "Target / indication"; }
  .pipeline-row > div:nth-child(3)::before { content: "Development stage"; }

  .site-footer {
    justify-items: center;
    padding: 34px 22px;
    text-align: center;
  }
}

@media (max-width: 430px) {
  .brand-mark {
    width: 36px;
    height: 36px;
  }

  .hero-visual {
    min-height: 300px;
    transform: scale(0.77);
    margin: -20px 0;
  }

  .hero-actions .button,
  .opportunity-actions .button {
    width: 100%;
  }
}

@media (prefers-reduced-motion: reduce) {
  html {
    scroll-behavior: auto;
  }

  *,
  *::before,
  *::after {
    animation-duration: 0.01ms !important;
    animation-iteration-count: 1 !important;
    transition-duration: 0.01ms !important;
  }

  [data-reveal] {
    opacity: 1;
    transform: none;
  }
}

/* Nanovia v9: simple single-page refinements */
.hero-cards-four {
  grid-template-columns: repeat(4, minmax(0, 1fr));
}

.hero-cards-four .feature-card {
  min-height: 190px;
}


.summary-grid {
  display: grid;
  grid-template-columns: minmax(0, 1.25fr) minmax(330px, 0.75fr);
  gap: 42px;
  align-items: start;
}

.summary-copy {
  color: var(--muted);
  font-size: 1.06rem;
  line-height: 1.72;
}

.summary-copy p:last-child {
  margin-bottom: 0;
}

.summary-points {
  padding: 28px;
  border: 1px solid var(--line);
  border-radius: var(--radius-lg);
  background: rgba(247, 252, 255, 0.92);
  box-shadow: 0 14px 34px rgba(18, 66, 101, 0.08);
}

.summary-points h3 {
  margin-bottom: 18px;
  color: var(--blue-700);
  font-size: 1.25rem;
}

.summary-points ol {
  display: grid;
  gap: 0;
  margin: 0;
  padding: 0;
  list-style: none;
}

.summary-points li {
  display: grid;
  grid-template-columns: 38px 1fr;
  gap: 14px;
  padding: 16px 0;
  border-top: 1px solid var(--line);
}

.summary-points li:first-child {
  padding-top: 0;
  border-top: 0;
}

.summary-points li > span {
  width: 34px;
  height: 34px;
  display: grid;
  place-items: center;
  border: 1px solid var(--line-strong);
  border-radius: 50%;
  color: var(--blue-700);
  background: var(--ice-100);
  font-size: 0.72rem;
  font-weight: 900;
}

.summary-points strong {
  display: block;
  margin-bottom: 4px;
  color: var(--navy-950);
}

.summary-points p {
  margin: 0;
  color: var(--muted);
  font-size: 0.88rem;
  line-height: 1.5;
}

.pipeline-row:not(.pipeline-header) > div:last-child {
  color: var(--muted);
  line-height: 1.5;
}

@media (max-width: 1050px) {
  .hero-cards-four {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }

  .summary-grid {
    grid-template-columns: 1fr;
  }
}

@media (max-width: 780px) {
  .hero-cards-four {
    grid-template-columns: 1fr;
  }

  .hero-cards-four .feature-card {
    min-height: 170px;
  }
}


/* Nanovia v11: same visual system, separate destination pages */
.home-page .site-footer {
  margin-top: 0;
}

.subpage-main {
  min-height: calc(100vh - var(--topbar-height));
  padding-top: 26px;
}

.subpage-main .content-section:first-child {
  padding-top: 46px;
}

.subpage-main .content-section:last-child {
  padding-bottom: 82px;
}

.page-utility {
  margin-bottom: 34px;
}

.page-utility a {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  color: var(--blue-700);
  font-size: 0.84rem;
  font-weight: 850;
}

.page-utility a:hover,
.page-utility a:focus-visible {
  text-decoration: underline;
  text-underline-offset: 4px;
}

.subpage .section-heading {
  margin-bottom: 42px;
}

.subpage .site-nav a[aria-current="page"]::after {
  transform: scaleX(1);
}

@media (max-width: 780px) {
  .subpage-main {
    padding-top: 8px;
  }

  .subpage-main .content-section:first-child {
    padding-top: 28px;
  }

  .page-utility {
    margin-bottom: 26px;
  }
}

/* Footer address and Development-page contact */

.development-contact {
  grid-column: 1 / -1;
  display: flex;
  justify-content: flex-end;
  padding-top: 6px;
}

.development-contact .button-light {
  min-width: 150px;
}

@media (max-width: 620px) {
  .development-contact {
    justify-content: stretch;
  }

  .development-contact .button-light {
    width: 100%;
  }
}

/* Nanovia supplied logo branding */
.brand-mark-image {
  overflow: hidden;
  padding: 3px;
  border-color: rgba(255, 255, 255, 0.72);
  background: #ffffff;
}

.brand-mark-image img {
  width: 100%;
  height: 100%;
  display: block;
  object-fit: contain;
  border-radius: 8px;
}

.hero-brand-logo {
  width: min(100%, 470px);
  height: auto;
  display: block;
  margin: -26px 0 14px;
  mix-blend-mode: multiply;
  filter: drop-shadow(0 10px 22px rgba(13, 63, 101, 0.08));
}

@media (max-width: 1050px) {
  .hero-brand-logo {
    margin-right: auto;
    margin-left: auto;
  }
}

@media (max-width: 780px) {
  .hero-brand-logo {
    width: min(100%, 390px);
    margin-top: -16px;
    margin-bottom: 10px;
  }
}


/* Nanovia v17: brand-first homepage and nanoparticle on executive summary */
.hero-logo-visual {
  position: relative;
  min-height: 430px;
  display: grid;
  place-items: center;
  padding: 18px;
}

.hero-logo-visual::before {
  content: "";
  position: absolute;
  width: min(92%, 430px);
  aspect-ratio: 1;
  border-radius: 50%;
  background: radial-gradient(circle, rgba(78, 151, 197, 0.12), rgba(78, 151, 197, 0.035) 52%, transparent 72%);
  pointer-events: none;
}

.hero-brand-logo-home {
  position: relative;
  z-index: 1;
  width: min(100%, 505px);
  margin: 0;
}

.summary-intro-grid {
  display: grid;
  grid-template-columns: minmax(0, 1.14fr) minmax(390px, 0.86fr);
  align-items: center;
  gap: 40px;
  margin-bottom: 42px;
}

.summary-intro-grid .section-heading {
  max-width: none;
  margin-bottom: 0;
}

.summary-hero-visual {
  min-height: 410px;
}

.summary-hero-visual .orbit-one {
  width: 365px;
  height: 365px;
}

.summary-hero-visual .orbit-two {
  width: 305px;
  height: 305px;
}

@media (max-width: 1050px) {
  .hero-logo-visual {
    min-height: 350px;
  }

  .summary-intro-grid {
    grid-template-columns: 1fr;
  }

  .summary-intro-grid .section-heading {
    text-align: center;
  }

  .summary-hero-visual {
    min-height: 390px;
  }
}

@media (max-width: 780px) {
  .hero-logo-visual {
    min-height: 285px;
    padding: 4px;
  }

  .hero-brand-logo-home {
    width: min(100%, 410px);
  }

  .summary-intro-grid {
    gap: 8px;
    margin-bottom: 28px;
  }

  .summary-hero-visual {
    min-height: 350px;
  }
}


/* Nanovia v20: Research & Publications */
.hero-cards-five {
  grid-template-columns: repeat(5, minmax(0, 1fr));
}

.hero-cards-five .feature-card {
  min-height: 200px;
  padding: 22px;
}

.research-summary {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 16px;
  max-width: 700px;
  margin: 8px 0 46px;
}

.research-summary > div {
  display: flex;
  align-items: baseline;
  gap: 14px;
  padding: 18px 20px;
  border: 1px solid var(--line);
  border-radius: var(--radius-md);
  background: rgba(255, 255, 255, 0.84);
}

.research-summary strong {
  color: var(--blue-700);
  font-size: 2rem;
  line-height: 1;
}

.research-summary span {
  color: var(--muted);
  font-size: 0.9rem;
  font-weight: 700;
}

.publication-section {
  margin-top: 34px;
}

.publication-section-secondary {
  margin-top: 54px;
}

.publication-heading {
  padding-bottom: 14px;
  border-bottom: 1px solid var(--line-strong);
}

.publication-heading h2 {
  margin: 0;
  color: var(--navy-950);
  font-size: clamp(1.45rem, 2vw, 2rem);
  letter-spacing: -0.03em;
}

.publication-list {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 16px;
  margin-top: 18px;
}

.publication-item {
  padding: 24px;
  border: 1px solid var(--line);
  border-radius: var(--radius-md);
  background: rgba(255, 255, 255, 0.84);
  box-shadow: 0 12px 28px rgba(18, 66, 101, 0.06);
}

.publication-meta {
  margin-bottom: 10px;
  color: var(--blue-700);
  font-size: 0.76rem;
  font-weight: 850;
  letter-spacing: 0.04em;
  text-transform: uppercase;
}

.publication-item h3 {
  margin: 0 0 10px;
  color: var(--navy-950);
  font-size: 1.05rem;
  line-height: 1.35;
}

.publication-item p {
  margin: 0;
  color: var(--muted);
  font-size: 0.9rem;
  line-height: 1.55;
}

.publication-list-compact {
  grid-template-columns: repeat(3, minmax(0, 1fr));
}

@media (max-width: 1180px) {
  .hero-cards-five {
    grid-template-columns: repeat(3, minmax(0, 1fr));
  }
}

@media (max-width: 900px) {
  .hero-cards-five,
  .publication-list,
  .publication-list-compact {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }
}

@media (max-width: 620px) {
  .hero-cards-five,
  .publication-list,
  .publication-list-compact,
  .research-summary {
    grid-template-columns: 1fr;
  }
}

/* v21: Source-linked research library. Other page layouts are unchanged. */
#research .research-summary { margin-bottom: 16px; }
.research-library-note { max-width: 780px; margin: 0 0 34px; color: var(--muted); font-size: .9rem; line-height: 1.65; }
#research .publication-item { display: flex; flex-direction: column; }
#research .publication-authors { font-size: .82rem; margin: 0 0 12px; }
.publication-links { display: flex; flex-wrap: wrap; gap: 12px 22px; padding-top: 20px; margin-top: auto; }
.publication-link { color: var(--blue-700); font-weight: 750; font-size: .9rem; text-decoration: underline; text-underline-offset: 4px; padding: 5px 0; }
.publication-link:hover { text-decoration-thickness: 2px; }
.publication-link:focus-visible { outline: 3px solid var(--blue-700); outline-offset: 5px; border-radius: 2px; }
#research .publication-rights { margin-top: 12px; font-size: .72rem; line-height: 1.5; }
.publication-rights a { text-decoration: underline; text-underline-offset: 2px; }
#research .publication-list-compact { grid-template-columns: repeat(2, minmax(0, 1fr)); }
@media (max-width: 620px) { #research .publication-list-compact { grid-template-columns: 1fr; } }


/* v28: official faculty bio beside the program-lead introduction. */
.summary-copy .summary-bio {
  margin-top: -0.25rem;
  margin-bottom: 1.4rem;
  font-size: 0.94rem;
}
.summary-bio-link {
  color: var(--blue-700);
  font-weight: 700;
  text-decoration: underline;
  text-underline-offset: 4px;
  text-decoration-thickness: 1px;
}
.summary-bio-link:hover { color: var(--navy-950); }
.summary-bio-link:focus-visible {
  outline: 3px solid var(--blue-700);
  outline-offset: 4px;
  border-radius: 2px;
}